Explore How BioSkryb Technology is Transforming Research at AMP 2023
BioSkryb Genomics is excited to participate in this year's AMP 2023 conference and connect with leaders in the molecular research and diagnostics field. This premier gathering of molecular professionals is the perfect venue to learn more about how BioSkryb is transforming single-cell analysis by enabling the most complete multiomic view of the cellular ecosystem, from discovery to diagnostics.
If you’d like to speak directly to primary template-directed amplification chemistry experts, visit Bioskryb’s island booth, #1719.
Join us for two special presentation tracks
While bulk sequencing has transformed cancer research and therapy, we are rapidly approaching the limits of discovery with bulk sequencing of tumors. Decreasing sequencing costs, increasing throughput, and improvements in methodology are enabling researchers to move from bulk to single-cell sequencing approaches. Furthermore, new chemistries are enabling multiomic analysis in single cells. In this workshop, learn how ResolveOME™, an integrated single-cell genomic and transcriptomic workflow, was used to characterize intratumoral heterogeneity in ductal carcinoma in situ cells.
Title: Discover tumor heterogeneity with integrated single-cell genomics and transcriptomics
Date: Wednesday, November 15, 2023
Time: 4:00 - 4:50 PM
Location: Room 251F
Innovation Spotlight Stage
Cell morphology is fundamental to patient sample evaluation. However, patient effusion samples contain limited tumor versus nonmalignant cells, limiting subsequent molecular analyses for therapeutic targets. We applied the Deepcell platform, which combines microfluidic sorting, brightfield imaging, and real-time deep learning interpretations based on multidimensional morphology, to enrich carcinoma cells. Carcinoma cell enrichment was validated with whole genome sequencing, enabled by single-cell whole genome amplification with BioSkryb’s ResolveDNA®. Enrichment showed a higher sensitivity for tumor fraction detection and somatic variant mutations versus presort samples. Our study demonstrates the feasibility and value of supplementing traditional cytology with multidimensional cell morphology.
Speaker: Weibo Yu, MD - UCLA
Title: Single-Cell Copy Number Variation Confirmed, Artificial Intelligence-Driven Morphology-Based Enrichment of Malignant Cells from Body Fluid
Date: Friday, November 17, 2023
Time: 3:00 - 3:30 PM
Location: Stage 2